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frlB [2019-08-26 12:50:46]
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frlB [2019-08-26 12:50:46]

fructoselysine-6-P-glycosidase
Locus
BSU_32610
Isoelectric point
5.44
Molecular weight
36.72 kDa
Protein length
328 aa Sequence Blast
Gene length
987 bp Sequence Blast
Function
metabolism of aminoacylated fructose
Product
fructoselysine-6-P-glycosidase
Essential
no
Synonyms
yurP
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of amino sugars
  • Metabolism → Amino acid/ nitrogen metabolism → Utilization of nitrogen sources other than amino acids → Utilization of amino sugars
  • Groups of genes → Membrane proteins
  • Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue

    • Gene

    Coordinates
    3,351,110 → 3,352,096

    The protein

    Modification

  • phosphorylated on Arg-48 PubMed

    • Structure

  • 3EUA

    • Localization

  • membrane associated PubMed

    • Additional information

  • belongs to the 100 most abundant proteins PubMed

    • Expression and Regulation

    Operons

    Genes
    frlB-frlO-frlN-frlM-frlD-yurJ
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • CodY: repression, PubMed, PubMed, in CodY regulon
  • FrlR: repression, PubMed, in FrlR regulon
  • YlxR: regulation, PubMed, in YlxR regulon

    • Regulation

  • FrlB: repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • induced in the absence of YlxR PubMed

    • Additional information

  • the frlB-frlO-frlN-frlM-frlD-yurJ operon is strongly downregulated in a cshA mutant PubMed
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    Genes
    frlB
    Description
    PubMed

    Regulation

  • frlB: repressed during growth in the presence of branched chain amino acids (CodY) PubMed
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    Biological materials

    Mutant

  • MGNA-A594 (yurP::erm), available at the NBRP B. subtilis, Japan
  • BKE32610 (ΔfrlB::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAATCCTTCACTCCTCGTT, downstream forward: _UP4_TGATCTGAAAATGAAGAACC
  • BKK32610 (ΔfrlB::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAATCCTTCACTCCTCGTT, downstream forward: _UP4_TGATCTGAAAATGAAGAACC

    • References

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